A Message from Our Executive Director Elizabeth Estes. OSIC — The Open Source Imaging Consortium. Portrait of Elizabeth Estes smiling.

Becoming Greater than the Sum of Our Parts

I’ve been traveling a lot lately and have had the privilege of spending time with some wildly brilliant and passionate scientists who work every day to make a difference for patients suffering from rare lung diseases around the world.

The travel has also given me something I don’t get very often: time to think. As someone who is closer to the end of my career than the beginning, I’ve found myself becoming a little reflective lately. Thinking about where we’ve been, what we’ve accomplished, and why we started this journey in the first place.

Nine years ago, OSIC was founded with one goal: radical progress for patients living with fibrosing lung disease, and for the families and caregivers who walk that journey alongside them.

Back then, I thought we were building a database.

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When the OSIC Database Becomes virtuOSIC

The OSIC Data Repository was instrumental to Coreline Soft’s development of an estimated FVC (eFVC) metric that can be calculated from chest HRCT scans.

During our 2025 Annual Member Meeting, Dr. Ryoungwoo Jang (장령우 박사), clinical research lead for Coreline Soft, discussed how eFVC shows promise as a tool for monitoring disease status, predicting progression, and assessing response to pharmaceutical treatments.

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From Core Lab to Clinic: AI Imaging Biomarkers

How can we improve patient care with AI-imaging biomarkers?

During our 2025 Annual Member Meeting, Dr. George Harston, chief medical and innovation officer at Brainomix, spoke about how OSIC has catalyzed Brainomix’s work in ILD and pulmonary fibrosis – both in clinical care and clinical trials.

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AI-Based Quantification of Airway Disease

How can AI-based quantification of airway wall thickening, airway dilation, and mucus impaction provide meaningful patient phenotypes?

During our 2025 Annual Member Meeting, Thironas’s Chief Innovation Officer Dr. Jean–Paul Charbonnier shared the results of several years of dedicated work to move airway analysis beyond single CT metrics toward comprehensive, quantitative characterization of airway conditions. 

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SEPI-IA: Advancing AI in Medical Imaging

OSIC member GMV is using our data repository in its work with SEPI-IA, a publicly funded Spanish research and innovation initiative aimed at developing AI tools for medical imaging of rare respiratory diseases. 

Carlos Illana Alejandro, GMV’s head of advanced health products, discussed the initiative’s objectives and work to date during our 2025 Annual Member Meeting, and explained how collaborating with OSIC is helping fuel GMV’s research.

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Unlocking Innovation in the OSIC Cloud

The OSIC Data Repository is the world’s largest and most diverse ILD database. Our partner for this platform, Sandra Stapleton and her team at VIDA, are constantly working to improve its features and make its plethora of powerful data even more accessible to users.

Sandra explored the repository’s latest enhancements during our 2025 Annual Member Meeting and demonstrated how these features streamline data access and accelerate research workflows.

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Beyond CT: How Optical Coherence Tomography Unlocks Microstructural Insight into Fibrosis

“Early detection and intervention are the keys to impacting outcomes in pulmonary fibrosis, COPD, and other lung diseases,” said Dr. Lida Hariri, associate professor of pathology at Harvard Medical School and Massachusetts General Hospital, during our 2025 Annual Member Meeting. 

Dr. Hariri discussed her work with optical coherence tomography and the different ways she’s been using this minimally invasive technology to help support early diagnosis and monitoring in ILDs.

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Generative AI in Action

Could interpretable survival models predict disease progression and patient outcomes better than traditional methods?

David Barber, a professor at University College London and OSIC’s computational science lead, spoke to this question during our 2025 Annual Member Meeting and discussed how his CenTime model can help drive more accurate predictions.

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Sarcoidosis: From Complexity to Clarity?

How do we tackle the complex data that comes from sarcoidosis – a rare, inflammatory disease characterized by granulomas that form in one or more organs – and create something we can work from to help find a cure?

The Foundation for Sarcoidosis Research (FSR) presented this challenge during our 2025 Annual Member Meeting. Elise Hoover, FSR’s vice president of research, discussed how FSR is helping combat sarcoidosis from all perspectives through its diverse research initiatives, Clinical Data Registry, and global collaborations.

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Bronchiectasis: A New Therapeutic Frontier

Can AI help detect clinical deterioration in bronchiectasis sooner? Can advances in phenotyping and endotyping enable precision medicine approaches? How can we extend our current knowledge of this disease out into the world?

Dr. Kevin Brown (National Jewish Health), Dr. Helmut Prosch (Medical University of Vienna and president of the European Society of Thoracic Imaging), and Prof. Luca Richeldi (Fondazione Policlinico Universitario A. Gemelli IRCCS) examined the evolving landscape of bronchiectasis research, clinical care, and quantitative imaging during a panel discussion at our 2025 Annual Member Meeting. They provided an integrated view of the disease, from clinical presentation and epidemiology to imaging interpretation and emerging AI-enabled approaches.

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