Powering Innovation in ILA & ILD Research with Global, AI‑Ready Data
Explore the Subpleural Lung in 3D
Transforming Data into Interactive Insights with OSIC Cloud
OSIC: A Global Force Transforming ILD Research
OSIC is a global, 501(c)(3) nonprofit cooperative uniting academia, industry and patient advocacy groups with a singular mission: to revolutionize research in interstitial lung diseases (ILDs) and rare fibrosing lung conditions. Central to this mission is the OSIC Cloud Data Repository — the world’s largest, most diverse ILD database dedicated to advancing knowledge and patient care worldwide.
Breaking Barriers Through Global Collaboration
Rare and complex diseases like ILDs demand more than cutting-edge technology — they require relentless momentum, shared expertise, and cross-border cooperation. ILDs affect people across every continent and culture. Only by harnessing diverse data and uniting stakeholders globally can we overcome the limitations of narrow datasets and develop solutions that reflect real-world diversity and complexity.
Building the OSIC repository has been a collaboration in its truest sense, with people from different disciplines, organizations, and countries all coming together on behalf of patients everywhere. This ability to collect and organize anonymized imaging and clinical data from across the world is the future of clinical science. We’ve seen efforts like this in common diseases, but nothing truly like it for rare diseases. As the OSIC database grows and we continuously learn from it, a real and substantial improvement in our ability to diagnose early, to predict outcomes, and to measure responses to therapy will be the result.
Unlocking Answers for Precision ILD Care
What specific ILD does my patient have? How will my patient respond to a particular therapy? What course of treatment should I recommend for the best possible outcome?
These are the critical questions facing healthcare professionals every day in the fight against ILDs. Machine learning offers a transformative solution — by harnessing universal, accessible algorithms to analyze digital patient data, it drives earlier diagnosis, sharper prognoses, and more effective disease management.
The challenge? No single center can gather enough patient data alone to fuel this progress. The OSIC Cloud changes the game. With its vast, diverse, real-world database, OSIC empowers the development of powerful algorithms that uncover answers and save lives. Its open science model ensures that every discovery is shared globally, accelerating personalized treatments and novel drug development for all patients.
Together, we are propelling the future toward a world where understanding ILDs is no longer a barrier to care. Our collective drive ensures that healthcare innovation reaches every patient, in every community, swiftly and precisely.
The OSIC Cloud:
Designed to Shape the Future of ILD Care
Built through a global alliance of radiologists, pulmonologists, machine learning experts, and imaging specialists, the OSIC Cloud is a trailblazing, data-rich resource. Housing anonymized images and clinical information from diverse, multi-ethnic, and multi-center sources, it delivers a realistic representation of ILDs available — surpassing any isolated study or dataset.
OSIC’s unique collaboration engine empowers every member to own their discoveries within a trusted ecosystem. As creators of the OSIC Cloud, we help accelerate scientific progress by providing access to multi-ethnic and multi-center datasets, platform usage for private and closed-loop trials, and a comprehensive knowledge hub with best-in-class educational and clinical research resources.
As a clinical radiologist and researcher focused on interstitial lung diseases (ILD), I’ve seen firsthand how difficult it is to make meaningful progress without access to diverse, well-curated imaging data. OSIC has fundamentally changed the landscape. The OSIC Cloud offers a scale and breadth of imaging and clinical information that simply hasn’t existed in ILD research before, and the platform itself is very well designed, being both user-friendly and powerfully practical. What sets OSIC apart is not just the data, but the way it brings together clinicians, scientists and industry in a truly collaborative environment. This kind of structure is rare, and it’s already accelerating the development of tools that can make a real impact on patient care.
About The OSIC Cloud Platform
The OSIC Cloud, powered by VIDA, is a secure platform for managing de-identified, curated real-world and clinical trial data — designed to fuel collaborative lung disease research.
THE OSIC CLOUD FEATURES
Data Security & Privacy Compliance
- GDPR- and HIPAA-compliant architecture
- Robust data backup and security
- Automated cloud-based pseudonymization and anonymization
- Role-based access controls tailored to user types
- Built-in open and restricted access functionality
High-Quality, AI-Ready Data Infrastructure
- Highly curated datasets
- Rigorous QC through automated and manual reviews
- Automated data normalization
Adaptability & Scalability
- Configurable for diverse research workflows
- Disease-agnostic, multi-omic platform
- Support for 13+ languages
Powerful Collaboration & Research Tools
- Smart data upload and customizable contribution tools
- Integrated case viewer
- Annotation tools for collaborative research
- Advanced search and filtering
Expertise Driving Clinical Trial Excellence
- Clinical trial workflows and features optimized for imaging
- Worklist and collection management
- Site training and certification
- 24/5 trial site support for imaging-related questions
- Dedicated Clinical Engagement Team for global site QC and procedures
- Online access to reference materials, including protocols and radiology manuals
Clinical & Educational Impact
- Embedded e-learning platform
MULTI-OMIC DATA
Training AI to Detect ILA
OSIC is enabling researchers to train deep learning models to do just that.
- Early ILA detection using LDCT and HDCT
- Stratification of “at-risk” populations
- Potential for earlier treatment and better outcomes
AI + OSIC = New frontiers in preventive pulmonology
Can AI learn a risk score?*
Unlocking Early Detection with AI ILA Risk Scoring
Enabling precision-driven, personalized management; minimizing missed and delayed diagnoses; enhancing outcomes through timely intervention.
Enabling Breakthroughs
Explore the Powerful Datasets Available Through OSIC
IMAGING MODALITIES
Standardized DICOM formats: HRCT, LDCT, X-ray, and Photon Counting CT (PCCT)
CLINICAL DATA
Curated and normalized from global contributors
PATIENT DIVERSITY
Ethics-cleared, internationally diverse population
ILD TYPES INCLUDED
IPF, Sarcoidosis, RA-ILD, Lung Cancer Screens, and more
AI COLLABORATION
Led by Prof. David Barber, OSIC’s ML lead and Director, UCL Centre for Artificial Intelligence
The future of medical research depends heavily on our ability to collate significant amounts of data available for detailed and open scientific investigation. It's a proud moment that OSIC is at the forefront of this movement. Data is the essence of scientific progress and the OSIC repository already contains preliminary data rich enough to better understand the causes of disease, leading to better treatment and patient outcomes.
The OSIC Cloud ILD Database: Data Overview
The OSIC Cloud Lung Cancer Screening/ILA Database: Pilot Overview
In a recent study of 1,384 individuals who received a lung cancer screening via CT scan, researchers identified “4% ILA in a lung cancer screening cohort; 37% had radiologic progression of ILA at 1 year and 40% were diagnosed with ILD within 5 years. Fibrotic ILA, defined by the presence of traction bronchiectasis, was a strong predictor of mortality, reduced progression-free survival, and diagnosis of ILD.”
The lung cancer cohort in our database will allow for future research to help identify biomarkers that can predict ILA/ILD disease progression.
The presence of ILA on a lung cancer screening is a significant finding that can increase the risk of developing ILD and may be associated with a higher risk of mortality. Early detection and appropriate management of ILA may crucial in preventing the progression to ILD and improving long-term outcomes.
See Innovation in Action:
Real Stories from OSIC Members
Discover how OSIC members and partners are harnessing the power of data to drive breakthroughs. OSIC Videos features compelling presentations that showcase transformative research and real-world impact.
Discover Innovative Research Utilizing the Global AI‑Ready OSIC Dataset
Explore groundbreaking studies using OSIC. Researchers worldwide are leveraging this rich resource to advance understanding and treatment of ILDs. With over 75 peer-reviewed publications and numerous conference presentations citing OSIC data, the data plays a pivotal role in driving innovation in fibrosing and rare lung diseases.
Accessing the OSIC Cloud
If you are an OSIC Member Institution,
please register to receive access to the OSIC Cloud.
Visit our membership page to learn more.